Abstract
Development of mouse skin tumors by 7, 12- dimethylbenz (a) anthracene and its prevention by C-phycocyanin involve the regulators of cell cycle and apoptosis
Highlights
There has been a considerable interest in the use of marine natural products for the chemopreventive activity against skin tumor development [1,2]
The spectrum of chemotherapeutic agents causing apoptosis has expanded progressively; we studied the effect of oral administration of food grade C-PC on some of the hallmark events of apoptosis and cell cycle regulators in mouse skin, a very well established model system as compared to other in–vivo models [9]. 7, 12-dimethylbenz (a) anthracene (DMBA) is commonly employed to induce skin tumors in mice
We show the chemopreventive effect of C-PC on chemically induced complete tumorigenesis and its basis in terms of cell cycle and apoptotic regulators at early or late stages after the DMBA exposure
Summary
There has been a considerable interest in the use of marine natural products for the chemopreventive activity against skin tumor development [1,2]. The spectrum of chemotherapeutic agents causing apoptosis has expanded progressively; we studied the effect of oral administration of food grade C-PC on some of the hallmark events of apoptosis and cell cycle regulators in mouse skin, a very well established model system as compared to other in–vivo models [9]. 7, 12-dimethylbenz (a) anthracene (DMBA) is commonly employed to induce skin tumors in mice. Mouse skin tumors can be induced using repeated topical applications of sub carcinogenic dose of DMBA in Swiss albino mice [10]. Present study deals with the effects of topical application of C-PC on some of the selective and critical events of apoptosis after DMBA exposure
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Integrative Pharmacology, Toxicology and Genotoxicology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
