Development of modified pulsincap drug delivery system of metronidazole for drug targeting

Abstract

A modified Pulsincap dosage form of metronidazole was developed to target drug release in the colon. Bodies of hard gelatin capsules were treated with formaldehyde keeping the caps as such. Metronidazole pellets prepared by extrusion-spheronization method were incorporated into these specialized capsule shells and plugged with polymers guar gum, hydroxypropylmethylcellulose 10K, carboxymethylcellulose sodium and sodium alginate separately at concentrations 20 mg, 30 mg and 40 mg. The filled capsules were completely coated with 5% cellulose acetate phthalate to prevent variable gastric emptying. All the formulations were assayed to determine drug content and the ability of the modified Pulsincap to provide colon-specific drug delivery was assessed by in vitro drug release studies in buffer pH 1.2 for 2 h, pH 7.4 (simulated intestinal fluid) for 3 h and pH 6.8 (stimulated colonic fluid) for 7 h. The results indicated that significant drug release occurred only after 5 h from the start of experiment. Thus, metronidazole could be successfully colon targeted by the use of the modified Pulsincap, thereby reducing systemic side effects.