Abstract
Purpose. A comparative morphological analysis of adult pancreas and newborn rabbits as acceptable model for obtaining of islet cell cultures having a low immunogenicity was agoal of this study. Materials and methods. Pancreas from adult and newborn rabbits and islet cell culture was examined by histological and immunohistochemical techniques. Results. Shown, the pancreas of adult rabbits contains great amount of exocrine tissue and culturing it does not allow to obtain the puri fi ed islets of impurities. By contrast, pancreas of newborn rabbits in which the ratio of the islets and the exocrine tissue is much higher, it is possible to obtain highly puri fi ed cultures of islet cells. Conclusion. Morphological features of newborn rabbit pancreas can use it as a model for obtaining cultures of islet cells having low immunogenicity.
Highlights
The pancreas of adult rabbits contains great amount of exocrine tissue and culturing it does not allow to obtain the purified islets of impurities
Morphological features of newborn rabbit pancreas can use it as a model for obtaining cultures of islet cells having low immunogenicity
5. Hawthorne W.Y., Simond D.M., Stokes R. et al Subcapsular fetal pig pancreas fragment transplantation provides normal blood glucose control in a preclinical model diabetes
Summary
Кроликов породы «Российская шиншилла» получали из специального питомника РАМН, обеспечивающего отсутствие у животных инфекционных заболеваний. В качестве доноров поджелудочной железы использовали взрослых (3-месячных) и новорожденных (1–3-дневных) кроликов
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