Development of MEMS Sensor for Detection of Creatinine Using MIP Based Approach – A Tutorial Paper

Abstract

Creatinine is a biochemical waste that is disseminated continually inside human blood. A synthetic polymer is developed in this study using Molecularly Imprinted Polymerization (MIP) technology with the precipitation polymerization method. The MIP polymer is used for finding the levels of creatinine from human serum samples with different creatinine concentrations. The MIP polymer is very selective to the specific adsorption of the molecules of creatinine. The produced MIP polymer is suitable for evaluating creatinine concentrations until 50 parts per million (ppm) that is thrice greater than the standard. The fabrication of chip-sized Micro-Electro-Mechanical-Systems (MEMS)-based interdigital (ID) sensors is described. The operation of the MEMS sensor is verified using the technique of Electrochemical Impedance Spectroscopy (EIS). The presented details of the development of MEMS ID sensor and creatinine specific MIP polymer are for detecting raised biotoxic waste levels, i.e. creatinine management is part of our research. The raised levels need monitoring by frequent pathological visits to those patients who have impaired kidney functioning. The complete system will be helpful for creatinine management at any time from home at a low cost. While early detection of an increase in creatinine and monitoring of kidney health to prevent further health-related complications are the goal of this research, results of up to 50 ppm are accessed. Until 50 ppm of MIP functionality is checked for confirming the MIP polymer adsorption of creatinine and the results are shown, which helps establish the sensing technology even if used for a patient with a high creatinine level.