Abstract
In situ film or liquid plaster, a medical product for topical use, was developed using various polymers and plasticizers. The film bases were formulated and evaluated for their physical appearances, tensile properties, integrity on porcine skin, powder x-ray diffraction (PXRD) and drug release. Formulations containing Eudragit® L100 and triethyl citrate (TEC) or PEG 400 represent good films. Benzalkonium chloride (BZCl), 0.4 % w/w, was also added in these formulations as anti-infective agents. Films containing Eudragit® L100 and TEC have revealed the most suitable properties as topically applicable plaster film: good physical appearance as well as adhesion on the porcine skin. A soft and tough film was also obtained from the formulation containing Eudragit® L100 and TEC. PXRD results have shown that drug exist in amorphous form in all formulations. The percentages of drug release among three formulations within 3 hours are between 8-12%. In conclusion, formulation containing Eudragit® L100 and TEC have revealed the most suitable properties as topically applicable plaster film.
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