Abstract
(DDC)2Zn, disulfiram (DS) metabolite, has shown promisinganticancer effects in vitro but further investigations in vivo are limited by itspoor water solubility. In this study, liposomes are assessed as a deliverysystem for (DDC)2Zn. Liposomes were prepared by the thin-filmhydration method, followed by high-pressure homogenisation (HPH) for sizereduction. The nano-liposomes were then characterised by size, polydispersityindex (PDI), zeta potential (ZP), drug loading and encapsulation efficiencies(DLE% and EE%), and MTT cytotoxicity assay. The HSPC-based (PBS) liposomesshowed a nano-range of sizes (< 200nm), good PDI (<0.5) but moderate EE%(<40%). However, (DDC)2Zn liposomal formulations showed enhanced cytotoxicactivities toward colorectal cancer cells. Therefore, liposomal formulations of(DDC)2Zn with improved DLE% and EE% might have immense potential incancer therapy.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
