Abstract
Leptospirosis is an acute infectious disease caused by Leptospira spp. that produces a broad range of health problems mainly in developing world. In several affected countries, a major attempt has been begun to find a potent and effective vaccine. This is while; the available vaccines neither perused immunological memory nor confer cross-protection. Four-week-old male hamsters were subcutaneously inoculated with four-leptospiral vaccine and four-control adjuvant through a triple-injection regiment at fortnightly intervals. Animals were bled through the saphenous vein weekly until the seventh week. We have demonstrated that adjuvant plays a fundamental role in the type and extent of the immune responses raised by leptospiral vaccination. We strongly recommend selection of alum in any formulation of leptospiral vaccine.
Highlights
Leptospirosis is an infectious disease caused by pathogenic bacteria genus Leptospira
Liptosipra pathologic mechanism is a combination of direct damages by the bacteria and the reactions arisen from the host immune system [21]
Researchers have found out that both internal and external cellular immune system are capable of being activated as a consequence of Liptosipra infection [22]
Summary
Leptospirosis is an infectious disease caused by pathogenic bacteria genus Leptospira. This bacterium could be transmitted from animals to humans. A major attempt has been begun to find a potent and effective vaccine. Mechanism of resistance against leptospira infection was thought to be primarily humoral response, recent studies pointed to a role for cellmediated immunity [11]. The purpose of our study is, investigation the effects of different adjuvants on the induction of humoral immunity in laboratory animal hamster and find the best formulation for this vaccine [12]
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