Abstract
Purpose: The presence of endogenous stem or progenitor cells in adult articular cartilage provided the rationale for the identification of small molecules that promote cartilage repair. The objective of this program was to improve the potency and pharmaceutical properties of previously identified small molecule Kartogenin (KGN), which stimulates chondrocyte differentiation of cartilage-derived progenitor cells, repairs articular cartilage in preclinical models and alleviates pain in rodents. In the current program, the optimization and development of the small molecule KA34 led to the investigation of it as an intra-articular regenerative therapy for osteoarthritis (OA) patients.
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