Abstract
A study on the development of sunscreen gel products from Momordica cochinchinensis(Lour.) Spreng. extract aimed to study phenolic content, inhibitory effect of Elastase and Tyrosinase, product stability, toxicity, astringent effect of M. cochinchinensis extract, skin elasticity value, suitable product formula calculation for preparing sunscreen gel products from M. cochinchinensis extract, and irritation test. The process started fromthe selection of raw materials, preparation of extracts for determining the total phenolic content, development of suitable formula, test of safety and product physical characteristics, and then test of the anti-allergic effect of 10 volunteers to get efficient and safe sunscreen gel from M. cochinchinensis extract. The study result indicated that M. cochinchinensisaril extract had antioxidant activity DPPH of 1.51±0.05 mg/ml, compared to standard substance - Vitamin C, and total phenolic content of 13.18±0.18 (mg equivalent of gallic acid per 100 g - dry weight). Regarding Cytotoxicity at a concentration of 0.0001-1 mg/ml, it revealed that M. cochinchinensisaril extract was not toxic to human skin cells with the cell survival percentage at a concentration of 1 mg/ml equaled to 95.35±1.86 and 88.15±4.73%, respectively. M. cochinchinensisaril extract concentration of 1 mg/ml had astringent effect which can stimulate human skin cells to move together faster than the control group but showed effect slower than Vitamin C concentrate of 1 mg/ml. and did not have inhibitory effect on Elastase and Tyrosinaseenzymes. Regarding M. cochinchinensis seed oil extract, it did not toxic to human skin cells at the concentration of 0.0001-1 mg/ml with the survival percentage equaled to 105.67-111.46%, and had a few antioxidants activity of unsaturated fatty acids with an IPC50 more than 1000 mg/ml. This study was only the development of sunscreen gel products from M. cochinchinensis extract.
Highlights
This research study aimed to develop sunscreen gel from M. cochinchinensis(Lour.) Spreng. extract, which is an herb that can be found and is avegetable that its fruit is normally used to make drinking water for nourishing eyesight and reducing blood sugar
Sunscreen gel product made from M. cochinchinensis extract was developed according Table 1
It can be summarized that Mc(S) at the concentration of 0.0001-1 mg/ml did not have any effect on human fibroblast skin cells and had a survival percentage between 105.67-111.46% whereas sodium lauryl sulfatehad toxic effect on cells at the concentration of 0.1 and 1mg/ml with survival percentage equaling to 12.03±1.82 and 9.13%, respectively.Mc(A) extract and vitamin C did not have toxic effect on human skin cells at the concentrate of 0.0001 - 1mg/ml with cell survival percentage equaled to 99.35±1.86 and 88.15±4.73%, respectively at the concentrate of 1mg/ml (Table 7).M. cochinchinensis aril extract did not possess tyrosinase and elastase inhibitory effects when compared with positive controls (Table 8)
Summary
This research study aimed to develop sunscreen gel from M. cochinchinensis(Lour.) Spreng. extract, which is an herb that can be found and is avegetable that its fruit is normally used to make drinking water for nourishing eyesight and reducing blood sugar. This research study aimed to develop sunscreen gel from M. cochinchinensis(Lour.) Spreng. The important substance in M. cochinchinensis, helps reduce inflammation, and M. cochinchinensis has 10-time higher beta-carotene than carrot, which helps nourish eyes. These important substances are extracted for using as the significant ingredient in making face cosmetics to decelerate wrinkles on the face because these essential substances possess high antioxidant property [1] and helps protect skin from harmful sunlight. Researcher brought M. cochinchinensis to develop sunscreen gel products to help society according to the sufficiency economy, keep generatinghigher incomes, expanding tourist attractions, and increasing community potential
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