Abstract
BackgroundDental implant has been successfully used to replace missing teeth. However, in some clinical situations, implant placement may be difficult because of a large bone defect. We designed novel complex biomaterial to simultaneously restore bone and place implant. This complex was incorporated implant into interconnected porous calcium hydroxyapatite (IP-CHA). We then tested this Implant/IP-CHA complex and evaluated its effect on subsequent bone regeneration and implant stability in vivo.Methodology/Principal FindingsA cylinder-type IP-CHA was used in this study. After forming inside of the cylinder, an implant was placed inside to fabricate the Implant/IP-CHA complex. This complex was then placed into the prepared bone socket in the femur of four beagle-Labrador hybrid dogs. As a control, implants were placed directly into the femur without any bone substrate. Bone sockets were allowed to heal for 2, 3 and 6 months and implant stability quotients (ISQ) were measured. Finally, tissue blocks containing the Implant/IP-CHA complexes were harvested. Specimens were processed for histology and stained with toluidine blue and bone implant contact (BIC) was measured. The ISQs of complex groups was 77.8±2.9 in the 6-month, 72.0±5.7 in the 3-month and 47.4±11.0 in the 2-month. There was no significant difference between the 3- or 6-month complex groups and implant control groups. In the 2-month group, connective tissue, including capillary angiogenesis, was predominant around the implants, although newly formed bone could also be observed. While, in the 3 and 6-month groups, newly formed bone could be seen in contact to most of the implant surface. The BICs of complex groups was 2.18±3.77 in the 2-month, 44.03±29.58 in the 3-month, and 51.23±8.25 in the 6-month. Significant difference was detected between the 2 and 6-month.Conclusions/SignificanceWithin the results of this study, the IP-CHA/implant complex might be able to achieve both bone reconstruction and implant stability.
Highlights
Dental implant has been successfully used to replace missing teeth
Interconnected porous calcium hydroxyapatite (IP-CHA) ceramics have been introduced for use as scaffold for bone regeneration [6], and are widely used in the clinical field [7,8,9,10]
Previous studies conducted in our laboratory demonstrated that both of cell-hybrid artificial bone where bone marrow stromal calls were injected to interconnected porous calcium hydroxyapatite (IP-CHA) and polyphosphate adsorbed IP-CHA could enhance bone formation [13,14,15,16]
Summary
Dental implant has been successfully used to replace missing teeth. in some clinical situations, implant placement may be difficult because of a large bone defect. We designed novel complex biomaterial to simultaneously restore bone and place implant This complex was incorporated implant into interconnected porous calcium hydroxyapatite (IP-CHA). If the functional implant site becomes infected, leading to peri-implantitis, the circumference of the affected bone in contact with the implant is resorbed, resulting in enlargement of the surrounding area owing to an inflammatory reaction In such cases, the implant and circumference of the affected bone require surgical removal, resulting in a large bone defect, which allows implant treatment only after bone reconstruction using some bone grafts, bone augmentation could be a tricky procedure, healing period may be very long, multiple surgeries are usually required, with a consequent increased risk of morbidity for patients due to the multiple step approach. Previous studies conducted in our laboratory demonstrated that both of cell-hybrid artificial bone where bone marrow stromal calls were injected to IP-CHA and polyphosphate adsorbed IP-CHA could enhance bone formation [13,14,15,16]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
