Abstract
Low compliance during consumption of antibiotics will result higher risk to antibiotic resistance. By modifying the release rate of the antibiotic, the patient will be able to consume antibiotics in less frequency while maintaining a stable drug concentration in the plasma, thus lowering the risk of antibiotic resistance. In this work, we report the use of hybrid hydrogels based on the Gelatine/Alginate/PVA as drug release controller of Cefixime, one of the most used antibiotics in Indonesia. The presence of Gelatine, PVA and Cefixime in the hydrogel system was analysed by FTIR spectroscopy. The release of Cefixime from the system is monitored under simulated gastric fluid. The results show that the release rate of the cefixime can be controlled by varying formulation of the hydrogels system. The presence of PVA in the formulation increase the release rate of the Cefixime.
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