Development of Highly Efficient NiO based Composite Materials for Ultra-Sensitive Glucose Sensors Non Enzymatic Glucose Sensors

Abstract

Diabetes is attracting a great attention because of alarming increase in death rate worldwide. Thus, in order to monitor blood glucose level and to prevent life-threatening impact of diabetes, researchers are consistently working on the development of highly sensitive, reliable, rapid and cost-effective electrochemical sensors for glucose detection. In this study, we plan to adopt green chemistry approach to synthesize NiO based composite materials via modified sol gel approach for glucose detection. The crystal structure and surface morphology of the as-synthesized materials were characterized by Powder-X ray diffraction (PXRD), electron microscopy (SEM) and BET surface area analyzer. Cyclic Voltammetry (CV) and Differential Pulse Voltammetry (DPV) methods were employed to investigate the catalytic properties of the fabricated electrode materials for glucose electro-oxidation in alkaline media. The NiO@Si-NPs developed non-enzymatic sensor exhibited excellent performance for glucose sensing with extremely low detection limit (0.08 μM) and an ultrahigh sensitivity of 445 μAm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> which could be attributed to the addition of silica nanoparticles on the surface of NiO that offered large surface area for oxidation of glucose. Hence, NiO@SiNps composite electrode materials will serve as a highly promising candidate for the development of efficient electrochemical sensors for reliable glucose detection.