DEVELOPMENT OF HERBOMINERAL FORMULATION FROM DAUCUS CAROTA (LINN) FOR WOUND HEALING EFFECTS

Abstract

A herbomineral formulation was developed in ointment form by using herb extract, mineral and other excipients and evaluated for wound healing effect in excision and incision wound models in rats. Excision wounds sized 500 mm2 and 2 mm depth were used to study the rate of contraction of wound and epithelialization at different time intervals. Incision wounds were used for the study of tensile strength measured on the 10th day. It was observed that the herbomineral formulation in the excision wound model possessed a significant (p<0.001) wound healing effect compared to a positive control group and was nearly comparable with a standard group. In incision wounds, the formulation showed a significant increase in the skin breaking strength compared to control and reference standards.The wound healing effect of the formulation may be attributed to phytoconstituents like flavonoid and phenolic derivatives present in the root extract.The herbomineral ointment was also evaluated for various pharmaceutical parameters and was found to be stable for 45 days.