Abstract
Development of Harmaline-induced Tremor in a Swine Model
Highlights
Pigs have been broadly and increasingly used as a large animal model in the biomedical and translational research fields due to the similarity of their internal organ anatomy and biochemical physiology to humans
Pigs have increasingly been used in the neuroscience and biobehavioral research fields because pigs have a compatible size and volume of the brain to non-human primates; and the anatomy and neurodevelopment of the pig brain is similar to the human brain
Here, we describe a protocol for development and characterization of a harmaline-induced tremor in the large animal pig model
Summary
Pigs have been broadly and increasingly used as a large animal model in the biomedical and translational research fields due to the similarity of their internal organ anatomy and biochemical physiology to humans. ET is the most frequent form of pathologic tremor and one of the most common adult-onset neurologic impairments.[5] The incidence rate for people age 60 and older is estimated at 6.3–9%.6 It affects approximately 10 million people in the United States.[5] Despite its high prevalence and disabling effects, pharmacological intervention only helps about 50% of patients with ET; and nearly one out of three patients stops taking their medications.[5] The development of new therapies has been hampered by a lack of knowledge about tremor pathophysiology and the lack of a validated preclinical model for Tremor and Other Hyperkinetic Movements http://www.tremorjournal.org. Our protocol provides reliable tremor in pigs and suggests pig as a valid translational large animal model of tremor
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