Abstract
Following birth there are changes in glomerular morphology and function reflected by an increased glomerular filtration rate (GFR). We wanted to determine if there are developmental changes in glomerular permeability associated with the increased GFR seen during early life.Clearance studies were performed in 12 lambs and compared to 4 adult ewes. Studies were performed shortly after birth and weekly where possible during the first 6 weeks of life. Creatinine (Cr), I125-Iodothalamate (I) and inulin (In) were administered as a bolus followed by constant infusion. The urine/plasma (U/P) ratio of I to Cr and In was determined. Then fluorescein labelled dextrans (D) mol. wgt. 3-70,000 daltons were infused. The D were chromatographed on LKB Ultrogel to separate them by mol. wgt. and analyzed by spectrophotoflurometry. U/P D / U/P I was plotted against effective D radius (A).Correlations of I versus Cr and In were CI=1.1 × CCr+6.7, r=0.9 and CI=0.9 × CIn+4.9, r=0.9 respectively. There was no significant difference in the D curves between the newborn, young or adult ewes.We conclude 1) changes in glomerular permeability for small molecules can not account for the increase in glomerular filtration rate seen during early extrauterine life. 2) Fluorescein labelled D can be used to determine glomerular sieving.
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