Abstract

A statistically significant decrease in the febrile index compared with the control was found in diabetic rabbits. Some delay was observed in the development of the leukocytic response, although there was no significant difference in the degree of leukocytosis in diabetic and control rabbits. Leukopenia, most marked in the control 18–20 h after the beginning of observation, was absent in some of the diabetic rabbits. No significant differences were found in the intensity of leukocytic infiltration of the inflammatory focus in the diabetic and control rabbits. Depression of the febrile response to aseptic inflammation in the diabetic rabbits was evidently connected with weakening of the ability of the leukocytes in the inflammatory focus to liberate pyrogenic products producing fever.

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