Development of fast Fourier transform continuous cyclic voltammetry at Au microelectrode in flowing solutions as a novel method for sub-nanomolar monitoring of lidocaine in injection and biological fluids

Abstract

In this work a novel method for the fast monitoring of lidocaine in flow-injection systems has been developed. The fast Fourier transform continuous cyclic voltammetry (FFTCV) at gold microelectrode in flowing solution system was used for determination of lidocaine in its pharmaceutical formulation. The presented technique was very simple, precise, accurate, time saving and economical, compared with all of the previously reported methods. The recommended technique demonstrated some advantages over other reported methods. Firstly, there was no need for the oxygen removal from the test solution. Secondly, a picomolar detection limit was achieved, and additionally, the method was fast enough for the determination of any such compound, in a wide variety of chromatographic methods. The method was linear across the concentration range of 240–1.1 × 10 5 pg mL −1 ( r = 0.996) with a limit of detection and quantitation 117.3 and 240 pg mL −1, respectively. As a conclusion this system offers the requisite accuracy, sensitivity, precision and selectivity to assay lidocaine in injections.