Abstract
Purpose: To develop an extended-release formulation of domperidone using a blend of Raphia hookeri gum and hydroxypropyl methylcellulose as tablet matrix.Methods: Tablets (400 mg) containing 30 mg domperidone (DPD) were formulated using binary mixtures of hydroxypropyl methylcellulose (HPMC) and Raphia hookeri gum (RHG) as matrix former; and microcrystalline cellulose (MCC) as direct compression excipient. The proportions of the matrix formers (40 % of tablet weight) was varied as 100:0, 75:25, 50:50, 25:75 and 0:100. The composition of the matrix former was also kept constant (50:50) while MCC was varied as 40, 30, 20 and 10 %. The tablets were evaluated for compact density, tensile strength, friability and drug release over 24 h.Results: The tensile strength of tablets decreased while their friability increased with increase in the proportion of RHG. A similar trend was observed with decrease in the concentration of MCC. Tablets containing RHG alone as matrix former and 40 % MCC as direct compression excipient had tensile strength of 0.95 MNm-2, friability of 1.07 % and cumulative drug release of 83.2 % over a period of 24 h. Tablets containing equal proportions of HPMC and RHG as matrix former had the best release properties of 95.0 % over a period of 24 h.Conclusion: RHG is comparable with HPMC in terms of extending the release of domperidone for a once daily administration. A suitable combination of the two polymers for use as a matrix former is superior to either of the individual polymers.Keywords: Domperidone, Extended drug release, Hydroxypropyl methylcellulose, Raphia hookeri gum, Tablet properties
Highlights
Tablets are the most popular pharmaceutical dosage forms having numerous advantages
This study was aimed at formulating an extended release system of the drug for once daily administration
The difference in weight was determined and the friability value was calculated as the ratio of difference in weight to the initial weight expressed as a percentage
Summary
Tablets are the most popular pharmaceutical dosage forms having numerous advantages. These advantages include: ease and low cost of production, high stability, possibility of masking objectionable odour and bitter taste, ease of product identification, portability, precise dosing and ease of administration [1]. It was observed that tablets containing RHG were characterized by better mechanical properties, longer disintegration time and slower dissolution rate This is a pointer to the suitability of the polymer for an extended delivery. The elimination half-life is 5 7 h, the oral bioavailability is 13 - 17 % and the adult dose is 10 mg three times daily [9] These pharmacokinetic parameters prompted the development of an extended release formulation of the drug using suitable polymers to reduce the frequency of administration of the drug. This study was aimed at formulating an extended release system of the drug (using a blend of Raphia hookeri gum and hydroxypropyl methylcellulose) for once daily administration.
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