Abstract
Objective To investigate the role of occult pancreatobiliary reflux in gallbladder car-cinogenesis. Methods The blood amylase and gallbladder bile amylase were measured, respectively,to diagnosis the occult pancreatobiliary reflux in 340 patients receiving selective cholecystectomy. The dysplasia and the proliferation activity in mucosa of gallbladders were detected histopathologically and immunohistochemieally. Results The incidence of occult pancreatobiliary reflux was 9.4% (32/340). One case of carcinoma and 11 cases of dysplasia were found in the 32 gallbladders with occult pancre-atobiliary reflux. The incidence of carcinoma and dysplasia was 37.5% in gallbladders with occult pan-creatobiliary reflux, which was higher than the control group with dysplasia incidence of 8.4% (P=0.006). The average Ki67 index was 24.4% in gallbladders with occult pancreatobiliary reflux, which was higher than the control group with Ki67 index of 13.2% (P=0.014). Conclusion The occult pancreatobiliary reflux is an important factor to induce gallbladder cancer. Key words: Gallbladder neoplasm; Occult pancreatobiliary reflux; Pathology; Immuno-histochemistry
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