Abstract
The diaphragm is the most important muscle for respiration with a bi-domed structure, which is separating thoracic cavity from abdominal cavity. Partial formation of diaphragm, with unknown reason during fetal development caused a birth defect called congenital diaphragmatic hernia (CDH). It allows the abdomen contents to go up into the chest cavity resulting in pulmonary hypoplasia, which is the major cause of the mortality. There are several types of membrane, which can be used as prostheses to close the existing hole. In this project, we study the tensile properties of electrospun PA-6 nanowebs and electrospun PA-6/B composite as substitution membrane by a comparison with the tensile properties of tendon part of pig’s diaphragm.
Highlights
The diaphragm is a layer of muscle and tendon that serves as the main part of respiration and plays a vital role in the breathing process
Gore-Tex® (PTFE) as a synthetic biocompatible material is used to patch this opening in University Hospital in Strasbourg/France
Diaphragm is contained of dense collagen fibres, arranged diagonally from lateral to medial direction
Summary
The diaphragm is a layer of muscle and tendon that serves as the main part of respiration and plays a vital role in the breathing process. If the opening in the diaphragm is small it can be sewn. Otherwise, if it has a large size the surgeon will require implanting an additional tissue or membrane. Gore-Tex® (PTFE) as a synthetic biocompatible material is used to patch this opening in University Hospital in Strasbourg/France (figure 1). The problem is that Gore-Tex® implantable membrane is not elastic enough to follow the natural growth of the child, so this patch usually requires replacement later by the child growth [2]
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