Development of Electro-Reduced AgNPs/MnO2/rGO Composite toward a Robust Sensor for the Simultaneous Determination of Piroxicam and Ofloxacin

Abstract

The presented investigation attempts to offer a robust, simple, cost-effective AgNPs/MnO2/ErGO composite to simultaneously determine piroxicam (PRX) and ofloxacin (OFX). The material is prepared via facile depositions of MnO2 and Ag species on graphene oxide followed by an electroreduction. The achieved composite (i.e., AgNPs/MnO2/ErGO) exhibits intimate interfacial contacts, promoting charge transfer and mass transport. Consequently, the sample AgNPs/MnO2/ErGO-decorated glassy carbon (GC) electrode (denoted AgNPs/MnO2/ErGO-GCE) signifies a remarkable capability to monitor PRX and OFX using differential pulse adsorptive anodic stripping voltammetry (DP-AdASV) technique. Indeed, the sensitivity values (MLD) have been found to be 0.063 and 0.077 μM for PRX and OFX, respectively, while maintaining high sensitivity, selectivity, repeatability, and stability. Impressively, the obtained electrode endows a remarkable performance in the determination of real antibiotic and water samples, which are compatible with the HPLC analysis, paving the way toward a high-performance electrochemical sensor for antibiotics.