Abstract
Layered hydroxides (LHs) have recently fascinated researchers due to their wide application in various fields. These inorganic nanoparticles, with excellent features as nanocarriers in drug delivery systems, have the potential to play an important role in healthcare. Owing to their outstanding ion-exchange capacity, many organic pharmaceutical drugs have been intercalated into the interlayer galleries of LHs and, consequently, novel nanodrugs or smart drugs may revolutionize in the treatment of diseases. Layered hydroxides, as green nanoreservoirs with sustained drug release and cell targeting properties hold great promise of improving health and prolonging life.
Highlights
The delivery of bioactive and therapeutic molecules is one of the most interesting areas of research with increasing growth and importance in medicine
As a result of the intercalation process, the thermal stability of the intercalated protocatechuic acid was significantly enhanced compared with free protocatechuic acid, and the protocatechuic acid anion was accommodated as a monolayer with an angle from the z-axis of 8° and 15° in PANE and PAND, respectively
The release at pH 4.8 occurred by dissolution of Zinc layered hydroxide (ZLH) layers, because ZLH is unstable in acidic media, while in pH 7.4, the release took place through the ion-exchange between the hippuric acid anions and anions in the buffer solution
Summary
The delivery of bioactive and therapeutic molecules is one of the most interesting areas of research with increasing growth and importance in medicine. Nanomaterials are materials with at least one dimension in the nanoscale range, which gives them unusual physical and chemical features, including quantum effect, high reactivity, and high surface area to volume ratio. Layered hydroxides (LHs) are inorganic materials that can be used as hosts to construct organic-inorganic nanocomposites. LHs are composed of nanolayers with two-dimensional infinite layers with nanoscale thickness and offer extensive applications in various areas. These host-guest layered solids can be classified as layered double hydroxides (LDH) and layered hydroxide salts (LHS)
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