Abstract
Methods A company, developed a range of test foods muffins, porridge, batter mix, lemon & almond cookies and chocolate krispie bars, containing the estimated average habitual child intake of gluten (5g) and/or casein (5g): Gluten and casein added (GACA); Added casein only (GFCA); Added gluten only (GACF). No gluten or casein added (GFCF). We aimed to recruit 60 children (3-6 yrs) with autism and to randomly allocate them to receive test foods from one the above groups (labelled A-D to maintain blinding) for 28 days alongside normal diet. Outcomes were measured by food consumption diaries, a test foods acceptability questionnaire and telephone interviews with a sub-set of parents.
Highlights
Autism is a severe long-term neurodevelopmental disorder
There is a need to investigate the efficacy of GFCF diets in an adequately powered, randomised controlled trial; double blinding to the removal of gluten and/or casein is desirable but complex to accomplish
We tested the feasibility of producing test foods to achieve
Summary
We aimed to recruit 60 children (3-6 yrs) with autism and to randomly allocate them to receive test foods from one the above groups for 28 days alongside normal diet
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