Abstract
According to the World Health Organization (WHO), one of the milestones set by the London Declaration for Chagas disease the interruption of Chagas disease transmission through blood transfusion in Latin America was achieved in most countries (20 out of 21) in 2015. This is a crucial step towards reaching the goal of controlling Chagas disease by 2020. However, many challenges remain: less than 1% of the 6 to 7 million people infected with Trypanosoma cruzi are treated, and new infections still occu
Highlights
Albert Picado1*, Andrea Angheben2, Andrea Marchiol3, Belkisyole Alarcon de Noya4, Laurence Flevaud5, Maria Jesus Pinazo6, Montserrat Gallego6,7, Sheba Meymandi8, Silvia Moriana9
Because T. cruzi can be transmitted by a variety of routes [6] and because the majority of people with chronic infection have never been tested and are not aware of their status, the development of new tools to diagnose Chagas disease is a priority
Progression test: Test to identify patients with a high risk of developing Chagas disease complications Test for early assessment of heart damage in Chagas disease patients Test for early assessment of digestive damage in Chagas disease patients Test for screening of drug resistance to benznidazole and/or nifurtimox
Summary
Because T. cruzi can be transmitted by a variety of routes [6] (i.e., vectorial transmission when T. cruzi parasites, which are released when the infected blood-sucking triatomine bugs defecate, enter the body via the skin break caused by the bug’s bite or via other mucosa [e.g., oral transmission through contaminated food]; congenital infection; blood transfusion; and cell, blood, or tissue transplantation) and because the majority of people with chronic infection have never been tested and are not aware of their status, the development of new tools to diagnose Chagas disease is a priority.
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