Abstract
In the present study, corn Starch-Neusilin UFL2 conjugates were prepared by physical, chemical, and microwave methods with the aim of using the conjugates as tablet superdisintegrant. Various powder tests, namely, angle of repose, bulk density, tapped density, Hausner's ratio, Carr's index, swelling index, and powder porosity were conducted on the samples. The conjugates were characterized by ATR-FTIR, XRD, DSC, and SEM techniques. Heckel and Kawakita models were applied to carry out compression studies for the prepared conjugates. Fast disintegrating tablets of domperidone were prepared using corn starch and corn Starch-Neusilin UFL2 conjugates as tablet superdisintegrants in different concentrations. Conjugates were found to possess good powder flow and tabletting properties. Heckel analysis indicated that the conjugates prepared by microwave method showed the slowest onset of plastic deformation while Kawakita analysis indicated that the conjugates prepared by microwave method exhibited the highest amount of total plastic deformation. The study revealed that the corn Starch-Neusilin UFL2 conjugates possess improved powder flow properties and could be a promising superdisintegrant for preparing fast disintegrating tablet. Also, the results sugessted that the microwave method was found to be most effective for the preparation of corn Starch-Neusilin UFL2 conjugates.
Highlights
Amongst innumerable applications, starch and its derivatives are one of the most widely used excipients in the pharmaceutical industry as they are incorporated in the manufacture of assorted dosage forms due to their biodegradability and biocompatibility
The aim of the present study is to evaluate the efficiency of a new conjugate of corn starch and Neusilin, as super disintegrating agent in the tablets
The specified quantity of the drug, diluent, and corn starch or corn StarchNeusilin UFL2 conjugates were weighed, accurately, passed through 60 mesh sieves (250 μm opening size), and mixed by tumbling method for 15 to 20 min
Summary
Starch and its derivatives are one of the most widely used excipients in the pharmaceutical industry as they are incorporated in the manufacture of assorted dosage forms due to their biodegradability and biocompatibility. As an antiadhering agent, increased the permeability of both maize and partially pregelatinized starch, resulting in compacts of high mechanical strength, short disintegration time, and low lubricant sensitivity Formulation with this novel excipient system, using paracetamol as a model drug, indicated its suitability as a single multifunctional excipient. Silicate/starch preparations have the potential to fulfil the requirements of a multifunctional excipient In this context the physical properties of compacts produced (disintegration time, tensile strength, and powder compressibility) and sensitivity towards lubrication need to be investigated. On this basis, the current study reports the application of silicates as an effective tabletting aid when used with corn starch [8, 9]. The dissolution rate and bioavailability of a poorly soluble drug from solid dosage form depend much on formulation additives and formulation characteristics
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