DEVELOPMENT OF COMPOSITION AND TECHNOLOGY OF CALCIUM-CONTAINING DRUG CAPSULES

Abstract

Aim. The aim of the study was to develop the composition and technology of calcium-containing drug capsules. Materials and methods. To optimize the choice of capsule composition, the method for mathematical planning of the experiment, Latin squire 3x3, was used. The experiment results were processed with mathematical methods of statistical and variance analysis using Dunkan, Fisher criterion, and generalized desired function. Technological properties and qualitative indices of capsules were determined by the generally accepted methods. Results. On the basis of the analysis of technological properties of substances and model capsules, it is necessary to use humid granulation and to add auxiliary substances (correcting substances, stickers and antifrictional substances) for avoiding the detected disadvantages and receiving qualitative capsules. Different compositions containing reactants such as calcium carbonate, ascorbic acid, vitamin D and auxiliary substances were formed. The influence of auxiliary substances, residual humidity and fractional composition of the granulated substance on technological parameters of the quality of mixtures and capsules of the chosen composition was studied. Conclusions. An optimal composition and rational technology of the drug “Calcium DS - Medisorb” is chosen; the corresponding size of solid gelatin capsules is selected that permitted to approbate this technology in production.