Development of Components of Prolonged Action Antibacterial Dosage Forms Using SCF Technologies

Abstract

Gentamicin and levofloxacin are encapsulated into bioresorbable polymer scaffolds and microparticles by the SCF methods: particles from gas saturated solutions (PGSS) and plasticization, with the subsequent foaming of amorphous polymers using supercritical carbon dioxide. The kinetics of the release of the incorporated drug substances into model physiological media are studied. It is shown that the use of the developed methods of SCF-encapsulation of drugs in bioresorbable carriers allows varying the size, shape, and morphology of the formed structures and, accordingly, the rate of release of the drugs into the physiological environments. In our opinion, this approach can be very promising for the development of components of new highly effective antibacterial prolonged action dosage forms.