Development of commercially feasible and Cost-effective tablet of Solifenacin succinate that can be compounded into an oral suspension

Abstract

In this research an attempt was made to develop and evaluate a commercially feasible and cost-effective tablet and oral suspension of Solifenacin Succinate. In international market, Solifenacin Succinate is available in both tablet and oral suspension dosage form. In Indian market, only tablet dosage form is available. Hence it was decided to make a formulation of Solifenacin Succinate that will not only be used as an oral solid dosage form in the form of tablet but also can be readily converted to oral suspension by extemporaneous means. A simple direct blending process was followed using limited excipients to make the end product cost-effective. The finalized product was comparable to the international brand product with respect to physico-chemical attributes, drug release and stability. The prepared tablet was made into an oral suspension using Ora-Plus® and Ora-Sweet® and the compounded suspension showed good palatability, organoleptics, chemical and microbial stability.