Abstract
Objective: This study is to enhance the solubility and sustained release of ciprofloxacin (CPX) drug by amplifying the adhesive capability of formulation by forming throat paint for the Streptococcal pharyngitis, a sore throat infection. Methods: Solid dispersion was prepared by solvent evaporation technique, in which three different ratios of Polyethylene glycol-6000 (PEG-6000) were selected, and the best ratio of solid dispersion was selected after characterization including Scanning electron microscopy (SEM) and Differential scanning calorimetry (DSC) with evaluation parameters including % yield, drug content, and drug solubility. In the case of throat paint, out of six different formulations, the best formulation was selected through viscosity, in vitro mucoadhesion, in situ release study, and spreadability parameters. Results: The DSC and SEM data proved that solid dispersion has a different moiety than its ingredients but it is quite a stable form. Formulation MD-2 was selected as the best formulation which able to increase the solubility of the drug by more than 3.5 folds, at the same time it shows the highest rate of drug dissolution of 13.951 μg/ml with % yield (97.199±0.167%) and drug content (96.425%). Throat paint was formed by fusion and trituration process and out of all six formulations F3 was selected as the best formulation on the basis of Viscosity (11932 Centi poise), Spreadability (17.621), Mucoadhesion (3937.481 dyne/cm2), and drug release (90.336±0.6%). Conclusion: Solid dispersion was successfully prepared with 3.5 times of solubility enhancement capability in comparison with pure CPX drug. The throat paint releases the drug (≥3 h) in a sustained manner with high mucoadhesive force.
Highlights
Whenever we deal with a disease that occurs in the buccal area, local drug delivery becomes our first choice, as it is easy to use and shows its benefits directly over the target
This kind of inflammation shows the symptom of a sore throat with a cough but as we know that sore throat is taken place because of viruses and only 5–10% of sore throat takes place because of bacterial infection, which is caused by Streptococcus bacteria, and disease caused by bacterial throat infection is called strep throat
Differential scanning calorimetry (DSC) DSC is always associated with measuring the heat which is either evolved and or absorb, so this technique was carried out to find the interaction between drug and polymer in which result revealed that in Fig. 3.8 image of a drug is having three peaks, at 155°, 165° and at 315°C. in which we found that the endothermic peak at 155°C which is very sharp proven the drug crystalline nature were as exothermic peak at 165°C proven that the drug is melted down and at the 315°C drug was degrade whereas in the peak of PEG-6000 which is used as excipient shown a peak at 165°C proven that the polymer was meltdown here
Summary
Whenever we deal with a disease that occurs in the buccal area, local drug delivery becomes our first choice, as it is easy to use and shows its benefits directly over the target. It’s a kind of inflammation of the pharynx, which is just present at the back of the throat This kind of inflammation shows the symptom of a sore throat with a cough but as we know that sore throat is taken place because of viruses and only 5–10% of sore throat (pharyngitis) takes place because of bacterial infection, which is caused by Streptococcus bacteria, and disease caused by bacterial throat infection is called strep throat. This kind of disease is commonly found in school-going children (3–15 year) but it may occur to anyone, this disease mainly includes sore throat with high efficiency of pain with difficulty in swallowing, mild fever, and swollen neck glands. Sometimes patients may be found with nausea and headache [3]
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