Development of Chemiluminescence Resonance Test System Using SiPM Front-end ASIC to Detect Na and K Ions in Urine

Abstract

The importance of measure and control dietary salinity arises to prevent and control the disease. There are several methods to measure the dietary salinities from blood or urine. The blood test is an accurate but inconvenient method because patients need to be at hospitals and wait for a longer time. Urine can be collected at home, and the test is more convenient. A 24-hour urine test is more accurate than random urine (RU) may cause more human errors. For this reason, testing RU accuracy for application will increase the convenience of patients. A SiPM sensor system to measure Guanine-based chemiluminescence resonance test light was developed. An ASIC system was developed and packaged to a chip. A test board for the packaged chip was developed. In parallel, the layout of an ASIC chip was assembled with SiPM and tested in the dark chamber to understand the functionality. The ASIC chip was tested in various frequencies with the test board. At the target frequency, the ASIC chip achieved 870 gain, which is exceeding the goal of 100. The SiPM system was measured with an oscilloscope, and the output signal was as expected. The performance test was done at a very high frequency (100MHz) and achieved 80.5% detection compared to the original light source signal. The ASIC chip development was successful, and SiPM matched the specification of the target operation.