Abstract
Efficient synthesis of trifluoromethylthiolated molecules, especially for chiral ones, is in great demand for the development of drugs. Developing new catalysis mode and new catalysts is the key to quickly expand this area. Our group discovered that Lewis basic chalcogenide catalysts could activate the N–SCF3 bond, which provided a new way for non- and asymmetric trifluoromethylthiolation. This Synpacts article highlights the recent advances we have achieved. 1 Introduction 2 Selenide-Catalyzed Nonasymmetric Trifluoromethylthiolation 3 Chiral Sulfide-Catalyzed Enantioselective Trifluoromethylthiolation 4 Conclusion
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