Abstract
Cerenkov luminescence imaging (CLI) is a new method of optical molecular imaging, which has been successfully applied in early clinical trials. However, weak signal intensity and limited ability in tissue penetration have impeded its clinical application. Cerenkov radiation energy transfer imaging and radiation excitation fluorescence imaging were adopted to solve these problems by enabling transformation of some of the blue-weighted Cerenkov luminescence (CL) spectra to red-shifted emissions, or by exciting rare earth particles to emit visible and near infrared light. This article reviews the development of Cerenkov signal enhancement by fluorescence excitation effect. Key words: Optical imaging; Radiation; Fluorescence; Trends
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