Abstract
We report the real-time and noninvasive detection of K+ release through cell membrane using a biologically-coupled field effect transistor (bio-FET). To achieve this purpose, the cell/transistor interface, which can selectively detect K+ release through the ion-channel, was developed. The K+ release through the ion-channel caused by apoptosis (programmed cell death) could be electrically detected using the bio-FET with crown ether monolayer. Thus we have demonstrated the ability to analyze selectively the ion channel behavior using the bio-FET modified with the functional monolayer.
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