Development of Broad-Spectrum Natural Sunscreens using Combinations of five Plant Species

Abstract

Introduction: Cancer is a range of multifactorial diseases which have in common uncontrolled increase in the number of cells invading various tissues and organs. One of its leading etiological agents is sun exposure, and therefore the use of sunscreens plays an important role in cancer prevention. Objective : In this context, the aim of this study was to verify whether the selected naturally-derived raw materials (Oli-ola dry extract, Hibiscus dry extract, Raspberry ketones, Leucoanthocyanidins isolated from grapes and Resveratrol) present adequate photoprotective properties for the development of an innovative broad-spectrum sunscreen. Methods: The determination of sunscreen activity was made in vitro , and the following parameters were obtained: Sun Protection Factor (SPF), UVA Protection Factor (UVAPF), Critical Wavelength and Boots Star Rating. Results: Innovative products showed varied results (maximum SPF=46; maximum UVAPF=22), being that all of them showed to be promising for both parameters. However, the greatest protection was shown in the UVB region. Conclusion: Thus, the Oli-Ola, Hibiscus, Leucoanthocyanidins, Raspberry Ketones and Resveratrol species, grouped in a cosmetic base lotion, showed potential for the development of innovative sunscreen products. Additionally, the SPF should be confirmed in vivo . Key words: Photoprotection, Natural sunscreens, Polyphenols, Flavonoids, Broad spectrum.