Abstract
Bone tissue engineering is an advanced field for treatment of fractured bones to restore/regulate biological functions. Biopolymeric/bioceramic-based hybrid nanocomposite scaffolds are potential biomaterials for bone tissue because of biodegradable and biocompatible characteristics. We report synthesis of nanocomposite based on acrylic acid (AAc)/guar gum (GG), nano-hydroxyapatite (HAp NPs), titanium nanoparticles (TiO2 NPs), and optimum graphene oxide (GO) amount via free radical polymerization method. Porous scaffolds were fabricated through freeze-drying technique and coated with silver sulphadiazine. Different techniques were used to investigate functional group, crystal structural properties, morphology/elemental properties, porosity, and mechanical properties of fabricated scaffolds. Results show that increasing amount of TiO2 in combination with optimized GO has improved physicochemical and microstructural properties, mechanical properties (compressive strength (2.96 to 13.31 MPa) and Young’s modulus (39.56 to 300.81 MPa)), and porous properties (pore size (256.11 to 107.42 μm) and porosity (79.97 to 44.32%)). After 150 min, silver sulfadiazine release was found to be ~94.1%. In vitro assay of scaffolds also exhibited promising results against mouse pre-osteoblast (MC3T3-E1) cell lines. Hence, these fabricated scaffolds would be potential biomaterials for bone tissue engineering in biomedical engineering.
Highlights
Bone is a porous natural composite with a variety of properties that can be used to heal or repair a fractured bone by replacing or reconstructing new tissues [1]
We developed polymeric nanocomposites with GG, acrylic acid (AAc), nano-hydroxyapatite (HAp NPs), nano titanium oxide (TiO2 NPs), graphene oxide (GO), and N,N’-methylene bisacrylamide (NN-MBA)
The absorption bands in the range of 1750–1628 cm−1 are attributed to the C−O stretching of GO and N,N’-methylene-bisacrylamide
Summary
Bone is a porous natural composite with a variety of properties that can be used to heal or repair a fractured bone by replacing or reconstructing new tissues [1]. Artificial tissue grafting has become increasingly popular in recent years as a way to overcome the limitations of traditional approaches (i.e., allograft or autografts). Pathogen transfer, pain, infection, and limited availability are all addressed [2,3]. Tissue engineering (TE) is a cutting-edge method of constructing and designing scaffolds that combines materials engineering and life science techniques to aid in the reconstruction and regeneration of new tissues. Bone regeneration, based on scaffolds, is vital for healing bone defects caused by trauma, tumors, resection, and bone deformities. For successful defected bone regeneration, interaction between bone-related cells and scaffolds is critical [4]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
