Development of Azo‐Based Fluorescent Probes to Detect Different Levels of Hypoxia

Abstract

Lass es leuchten: Neue Hypoxie-sensitive Fluoreszenzsonden bestehen aus einer Rhodamin-Einheit mit einem Azo-Substituenten in direkter Konjugation zum Fluorophor. Aufgrund sehr schneller Konformationsänderung entlang der NN-Bindung fluoreszieren die Verbindungen nicht unter Normoxie; unter hypoxischen Bedingungen wird jedoch die Azo-Einheit reduziert, und ein stark fluoreszierendes Rhodamin-Derivat wird freigesetzt. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.