Abstract
It was shown that the synthesized camphene sulfone, in contrast to acetylsalicylic acid and clopidogrel, completely inhibits the activation of platelets induced by adrenaline and arachidonic acid, and reduces the influence of ADP, collagen, and ristocetin. Detailed NMR studies and molecular dynamics simulations using model SDS membranes indicated that the sulfone is embedded by its bicyclic part inside the SDS micelle, whereas -SO2(CH2)2OH fragment of sulfone is located on the outer part of the micelle and accessible for solvent. It was ascertained that hemocoagulant activity of sulfone is caused by its capability of inhibition of platelet activation and suppression of catalytic activity of phospholipid surface participating in formation of coagulation complexes of clotting factors.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
