Abstract
A triplex-forming oligonucleotide (TFO) can bind to genomic DNA and inhibit the expression of genes with specific sequences. However, to date, there have been a few reports of modified bases in antiparallel TFOs that can recognize and strongly bind to T–A base pairs. In this study, we introduced several quinoline derivatives into antiparallel TFOs to develop modified bases that can recognize the T–A base pair and evaluated their ability to form triplexes and to discriminate between base pairs. The introduction of 2-acetamido-6-aminoquinoline6DAQac) into an antiparallel TFO allowed the selective recognition of a T–A base pair at both low and high salt concentrations.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
