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Abstract
The elimination of circulating lymphocytes in patients exhibiting autoimmune disease symptoms (e.g., rheumatoid arthritis) results in marked improvement of the signs and symptoms of the disease. The authors investigate the feasibility of using a hollow cylindrical ultrasonic transducer implanted in the patient to destroy the thoracic duct lymphocytes. Cultures of human peripheral blood lymphocytes are exposed, in vitro, to ultrasound waves. Measurements of thoracic duct flow rate, heating of the cell medium, voltage and frequency applied to the ultrasonic transducer in a pulsed or continuous mode of operation are investigated along with the optimization of these parameters. The advantages of an ultrasound device over other radiative sources were reported.
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