Abstract
Cancer stem cells (CSCs) play a vital role in cancer progression, maintenance of tumor tissues, and are likely to be the source of tumor recurrence and metastasis. Thus, CSCs are a promising therapeutic target in cancer. The development of novel therapeutic interventions based on the characterization of CSCs is needed to overcome their resistance to conventional anti-cancer therapies. Unfortunately, the separation and purification of the CSCs from human tumor tissues is complicated by a plethora of technical difficulties that prevent the discovery of new anti-CSC drugs. We recently developed a method for preparing induced CSCs by oncogenic reprogramming of non-tumorigenic human mammary epithelial MCF-10A cells via the transduction of defined reprogramming factors. This model is a unique tool not only for analyzing the properties of CSCs but also for screening drugs that selectively target CSCs.
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