Development of an Implantable Wireless and Batteryless Bladder Pressure Monitor System for Lower Urinary Tract Dysfunction.

Yihua Zhong,Zhaohui Ren,Bolin Qian,Junming Deng,Yaguang Zhu,Jinghua Liu,Xu Zhang,Qianrui Bai

doi:10.1109/jtehm.2019.2943170

Yihua Zhong, Zhaohui Ren + Show 6 more

Open Access

https://doi.org/10.1109/jtehm.2019.2943170

Copy DOI

Abstract

Background: Closed-loop neuromodulation based on bladder pressure is an effective therapy for lower urinary tract dysfunction. The catheter-based cystometry normally used for bladder pressure measurement is not conducive to patient health because it will bring great mental stress to the patient and increase the risk of infection. Method: This paper designs and implements an implantable wireless and batteryless bladder pressure monitor system that monitors bladder storage in real time by implanting a miniature packaged sensor which transmits the feedback signal to the external receiver through BLE (Bluetooth Low Energy). The implanted part is powered by a dedicated magnetic resonance based wireless power transmission system, which means no battery is needed. Results: The maximum distance to which power can be transmitted is 7cm. The in vitro experiment proves that the system performance can meet the requirement of bladder pressure monitoring. The animal experiment uses rabbits as a model to verify the effectiveness of the system. After implantation, this system can work for a long time without replacing the battery. Conclusion: This system can monitor the pressure of the bladder and provide a basis for Closed-loop neuromodulation in patients with lower urinary tract dysfunction.

Highlights

Neurogenic bladder is a type of disease that causes lower urinary tract dysfunction due to nervous system disease
The system consists of a wireless power emitter, a tablet receiver and an implantable sensor module
The test result of the maximum working distance shows that the pad receiver can get the pressure data as long as the distance between the wireless power emitter and the implantable sensor module is less than 7cm

Summary

Introduction

Neurogenic bladder is a type of disease that causes lower urinary tract dysfunction (i.e., urine storage and urination dysfunction) due to nervous system disease. It will result in a series of symptoms like urinary incontinence, urinary retention and frequent micturition. Closed-loop neuromodulation based on bladder pressure is an effective therapy for lower urinary tract dysfunction. The animal experiment uses rabbits as a model to verify the effectiveness of the system After implantation, this system can work for a long time without replacing the battery. Conclusion: This system can monitor the pressure of the bladder and provide a basis for Closed-loop neuromodulation in patients with lower urinary tract dysfunction

Methods

Results

Conclusion