Development of an Immunotropic Drug Based on Coordination Compounds of a Synthetic Low Molecular Weight Thymus Peptide with Iron Ions

Abstract

We describe here the development of the immunomodulatory agent timofer, which is a 0.0148% aqueous solution of coordination compounds of the dipeptide isoleucyl-tryptophan and iron (II) sulfate; the synthesis of the free dipeptide and the medicinal formulation timofer and its production technology are described. Interactions were studied and the composition of the coordination compounds of the isoleucyl-tryptophan dipeptide with the iron (II) ion was identified. Interaction of the peptide and a metal ion in aqueous solution was shown to result in the formation of several complex forms, due to a stepwise complex formation process.