Abstract
Salvinorin A (Sal A) which is the neoclerodane ditrepene and is an extremely potent and highly selective kappa opioid receptor agonist, is the main active constituent isolated from the leaves of S. divinorum. It is a powerful psychoactive perennial herb, belongs to Lamiaceae family. Sal A has been shown to have various pharmacological activities. We have successfully prepared monoclonal antibodies (MAb) against Sal A, and developed an enzyme-linked immunosorbent assay (ELISA) system for determination of Sal A. A single-chain variable fragment (scFv) which is a kind of recombinant antibodies for Sal A was prepared and used in an ELISA. The recombinant antibodies which are derived from a MAb against Sal A prepared by us was expressed by Escherichia coli cells and characterized regarding their reactivity and specificity.
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