Abstract
Facile and environment-friendly procedure for the synthesis of corresponding 3,4-dihydropyrimidin-2-(1 H )-ones/thiones derivatives were developed via one-pot three-component Biginelli reaction between β-keto esters (methyl or ethyl acetoacetate), aromatic aldehyde (benzaldehye derivatives) and urea or thiourea in the presence of Lanthanum (III) Nitrate Hexahydrate ( La(NO 3 ) 3 .6H 2 O ) as highly efficient catalyst under solvent-free conditions. This protocol has advantages such as readily, inexpensive and non-toxic catalyst, simple reaction work-up catalyst , high atom-economy, excellent yields and short reaction times.
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