Abstract
AbstractA conductive engineered cardiac patch (ECP) can reconstruct the biomimetic regenerative microenvironment of an infarcted myocardium. Direct ink writing (DIW) and 3D printing can produce an ECP with precisely controlled microarchitectures. However, developing a printed ECP with high conductivity and flexibility for gapless attachment to conform to epicardial geometry remains a challenge. Herein, an asymmetrical DIW hydrophobic/hydrophilic membrane using heat‐processed graphene oxide (GO) ink is developed. The “Masked spin coating” method is also developed that leads to a microscale GO (hydrophilic)/reduced GO (rGO, hydrophobic) physiological sensor, as well as a macroscale moisture‐driven GO/rGO actuator. Depositing mussel‐inspired polydopamine (PDA) coating on the one side of the DIW rGO , the ultrathin (approximately 500 nm) PDA‐rGO (hydrophilic)/rGO (hydrophobic) microlattice (DrGOM) ECP is bestowed with the flexibility and moisture‐responsive actuation that allows gapless attachment to the curved surface of the epicardium. Conformable DrGOM exhibits a promising therapeutic effect on rats' infarcted hearts through conductive microenvironment reconstruction and improved neovascularization.
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