Abstract
Amphotericin B is a broad spectrum antifungal agent used to treat fungal infections. Organogel is a semisolid preparation in which the apolar phase gets immobilized within spaces of the three-dimensional structure. The current study aimed at the formulation and comparative evaluation of sorbitan monostearate organogels and pluronic lecithin organogels (PLO). Different compositions of span 60 based organogels were prepared by varying the concentrations of the span 60 and PLO gels were prepared by varying the concentration of Pluronic F 127. The developed organogels were subjected to various characteristics such as pH, viscosity, spreadability, extrudability, and drug release studies. The optimized formulations were evaluated against Candida albicans and carried out ex vivo release study. The optimized formulation was selected from span 60 based organogels, and pluronic lecithin organogels were S1 and P1, respectively. The optimized formulation (S1) showed effective inhibition against Candida albicans. The skin irritation test was carried out on albino mice for optimized formulations and results showed that no irritation to the skin. Based on the results, organogels prepared by sorbitan monostearate showed better antifungal activity, and also all the formulations were found to be stable and safe throughout the study period.
Highlights
For many decades, topical drug delivery system is considered as the best and easiest way of administration of therapeutic agents for local effect; it shows some systemic effects
Various topical formulations are available such as cream, gel, lotion, but these are undesirable for many drugs due to its poor absorption and other side effects. To avoid all these drawbacks, it is a new idea to prepare a formulation of organogel incorporating with amphotericin B as the therapeutic agent
Sorbitan monostearate based organogels were prepared by a simple method, in which required the amount of span 60 was dissolved into isopropyl myristate (10% w/v) in a beaker and 2% w/v of polysorbate was added to the above solution
Summary
Topical drug delivery system is considered as the best and easiest way of administration of therapeutic agents for local effect; it shows some systemic effects. Various topical formulations are available such as cream, gel, lotion, but these are undesirable for many drugs due to its poor absorption and other side effects To avoid all these drawbacks, it is a new idea to prepare a formulation of organogel incorporating with amphotericin B as the therapeutic agent. Organogel has better penetration power through the skin layers without any chemical catalyst, and it is a good carrier for lipophilic drugs. These novel drug delivery systems can produce controlled drug delivery; it can significantly improve its performance in terms of efficacy, safety and stability (Xie et al, 2014)
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