Abstract
AbstractStudies were conducted to develop agglomerated talc as a tablet diluent using the fluidized-bed granulation method. A complete 23 factorial experiment was run using a Uniglatt fluidized bed granulator to determine the effects of atomizing air pressure (P), inlet air temperature (T), and the quantity of the granulating fluid (V) upon the characteristics of the resultant agglomerated talc. It was found that the atomization pressure was the most prevailing factor for controlling the growth of the agglomerates in the granulation process. With the decrease of the atomizing air pressure, the geometrical mean particle size and flowability of the agglomerates increased. The volume of the binder solution (dilution effect) affects the properties of the agglomerates in the same direction as did the atomizing air pressure. Droplet size distribution of the atomized binder solution was estimated. The result suggested that the dilution effect altered the properties of the product through its adhesivity. The flow...
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