Development of Acute Renal Failure after Magnetic Resonance with Gadopentetate

Abstract

Gadolinium (Gd) based contrast materials are traditionally considered non nephrotoxic. In the past, acute renal failure (ARF) has been reported after gadolinium administration in some publications. A 65 year old female patient was underwent upper abdominal MR examination. She had no history of diabetes, hypertension and kidney problems. Neither there was any history of NSAIDs nor nephrotoxic agents. During examination process, 50mg gadopentetate was used. Three days later, rapidly progressive anuric acute renal failure developed. In anesthesia intensive care unit, she was underwent dialysis for six sessions. Her renal biopsy was carried out and its results turned out to be acute tubular necrosis and acute intersistial nephritis. Acute renal failure improved after subsequent hemodialysis sessions. General condition and laboratory values improved, all treatment was gradually withdrawn and and the patient was discharged without any complications.