Abstract
A Love wave-based biosensor with a 440 MHz operating frequency was developed for simultaneous detection of two different concentrations of anti-dinitrophenyl-keyhole limpet hemocyanin (Anti-DNP-KLH) rabbit immunoglobulin G (IgG) in a single sensor. The sensor was composed of surface acoustic wave (SAW) reflective delay lines built from interdigital transducer (IDT) and several reflectors, a poly(methyl methacrylate) (PMMA) waveguide layer, and two sensitive films. To extract optimal device parameters, coupling of mode (COM) modeling was carried. According to the device parameters determined, the Love wave biosensor was fabricated and then wirelessly characterized by a network analyzer. Binding of anti-DNP IgG to DNP induced a change in the time positions of the original reflection peaks mainly due to the mass loading effect. The measured time positions were matched well with the predicted values from COM modeling. The sensitivities evaluated from the first and second sensitive films were 167.9 and 44.8 deg·µg-1·ml-1, respectively.
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