Abstract
This paper reports the development of a three-channel automatic speed-matching climbing training system that could train three rats at the same time for rehabilitation after an ischemic stroke. An infrared (IR) remote sensor was installed at the end of each channel to monitor the real-time position of a climbing rat. This research was carried out in five stages: i) system design; ii) hardware circuit; iii) running speed control; iv) functional testing; and v) verification using an animal model of cerebral stroke. The rehabilitated group significantly outperformed the middle cerebral artery occlusion (MCAo) sedentary group in the rota-rod and inclined plate tests 21 days after a stroke. The rehabilitated group also had a cerebral infarction volume of 28.34±19.4%, far below 56.81±18.12% of the MCAo group 28 days after the stroke, validating the effectiveness of this training platform for stroke rehabilitation. The running speed of the climbing rehabilitation training platform was designed to adapt to the physical conditions of subjects, and overtraining injuries can be completely prevented accordingly.
Highlights
Stroke is the most common cause of adult disability worldwide. It affects patients’ behavior, cognition, learning, and memory, and causes many inconveniences and psychological stresses in daily life, and degrades the quality of life [1]. It results in a heavy financial load to governments, and an issue of immediate concern is to develop an effective rehabilitation mechanism
The infarction size and the edema caused by middle cerebral artery occlusion (MCAo) can be reduced by at least two weeks of treadmill pre-training [5]; subjects benefit more from forced than voluntary exercise due to increased cerebral metabolism, and this observation applies to neuron protection [6]
The experimental results showed no significant difference in the volume of cerebral infarction between the treadmill group (68.66±5.89%) and the sedentary group (56.81±18.12%), indicating no significant improvement in stroke rehabilitation in the treadmill group
Summary
Stroke is the most common cause of adult disability worldwide It affects patients’ behavior, cognition, learning, and memory, and causes many inconveniences and psychological stresses in daily life, and degrades the quality of life [1]. It results in a heavy financial load to governments, and an issue of immediate concern is to develop an effective rehabilitation mechanism. Forced treadmills [5,6] and forced [7] and voluntary running wheels [8] remain the most common training platforms for clinical research and animal model validation. The above-referred training platforms all have their own disadvantages, as explained below
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